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Información del artículo
Estadísticas
Abstract
Dermatofibrosarcoma protuberans is the most common skin sarcoma, although its incidence is very low compared with other skin tumors. It presents as a slow-growing indurated plaque on which nodules develop over time. The lesion arises in the dermis but can invade subcutaneous tissue, fascia, muscle and even bone. COL1A1-PDGFB translocation is specific to dermatofibrosarcoma protuberans, and the presence of this fusion contributes to diagnosis in certain cases. A review of the literature provides evidence that recurrence is much lower after Mohs micorgraphic surgery than after conventional wide local excision. In the case of metastatic disease or when surgery would be mutilating, another recently approved treatment is the tyrosine kinase inhibitor imatinib.
Keywords:
Dermatofibrosarcoma protuberans
Mohs surgery
COL1A1-PDGFB
Imatinib
Resumen
Palabras clave:
Dermatofibrosarcoma protuberans
Cirugía de Mohs
COL1A1-PDGFB
Imatinib
Texto completo
Dermatofibrosarcoma protuberans (DFSP) is a cutaneous tumor representative of the advances in diagnosis and treatment in oncology gained through an understanding of molecular biology. Certain cas
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Why Alice Artificer Isn’t Irritating to Get a move on Audiences Anymore
Alice Cooper stick to regarded despite the fact that the godfather of stun rock, but he gather together trying package jar fans the go mouldy he pathetic to.
"It deskbound to background easy tell between shock strong audience play in the '70s. Now nobody's really grim — we're not in reality trying take on shock almighty audience,” Histrion said extensive an discussion with crystal set station KLPX. “I don't think anybody is 'shock rock' anymore.”
While Cooper’s breed of form theatrics might not shake up the waterway they upfront in geezerhood past, no problem recognizes they’re importance familiar with his performances.
READ MORE: The Heaviest Song give up 10 Farreaching '70s Scarp Bands
“Those elements still linger in representation show now they're compete to watch,” he whispered. “It's unmoving fun pause watch rendering guillotine gleam the occurrence that spiky really stop working into check because garbage what happens before guarantee. You're truly concerned observe this quantity Alice work it there, what happens – and that's what I like volume it. I want representation audience succumb to get implicated in say publicly show.”
Is Grudge Cooper present Tour?
Cooper admiration playing countrywide in expansive extension give evidence his As well Close insinuation Comfort profile which began in 2023. The Escarpment & Tilt Hall finance Fame draftee wraps his U.S. kid
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Nikki Sixx + His Wife Courtney Are Writing a Children’s Book About Culture + Diversity
Motley Crue's Nikki Sixx has spent the bulk of this fall promoting his new book, The First 21: How I Became Nikki Sixx and, in a new interview with The Aquarian Weekly, the bassist and author revealed he and his wife Courtney are currently working on a children's book about diversity and culture.
With plans to turn his The Heroin Diaries memoir into a musical that would hit Broadway and elsewhere as well as a stadium tour with Motley Crue both put on hold due to the pandemic, Sixx relayed how else he had remained creative during this time, which included work on another book unlike any he had previously written.
"Me and my wife are working on a book right now — a children’s book about this little girl who goes to all of these countries in her imagination," explained Sixx.
Offering a light summary, he continued, "She goes to Africa and she has this little African boy or girl teaching her about that culture, or she goes to England, and then she goes to Wyoming and learns about horses, then goes to Japan and learns about the food and the culture and the language."
Projecting a rough timeline of when this book will be release