Biography karam khellah

  • Bone metastases cause substantial morbidity and implicate worse clinical outcomes for clear-cell renal cell carcinoma patients.
  • The aim of this study was to evaluate the applicability of cancer-related miR-210, miR-218, miR-221 and miR-1233 as prognostic biomarkers for RCC.
  • MiR-221-5p is significantly up-regulated in RCC tissues and RCC cell lines.

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    Abstract

    Simple Summary

    Bone metastases cause substantial morbidity and implicate worse clinical outcomes for clear-cell renal cell carcinoma patients. MicroRNAs are small RNA molecules that modulate gene translation and are involved in the development of cancer and metastasis. We identified six microRNAs that are potentially specifically involved in metastasis to bone, of which two seem protective and four implicate a higher risk. This aids further understanding of the process of metastasizing to bone. Furthermore, these microRNA hold potential for biomarkers or therapeutic targets.

    Abstract

    Bone metastasis in clear-cell renal cell carcinoma (ccRCC) leads to substantial morbidity through skeletal related adverse events and implicates worse clinical outcomes. MicroRNAs (miRNA) are small non-protein coding RNA molecules with important regulatory functions in cancer development and metastasis. In this retrospective analysis we present dysregulated miRNA in ccRCC, which are associated with bone metastasis. In particular, miR-23a-3p, miR-27a-3p, miR-20a-5p, and miR-335-3p specifically correlated with the earlier appearance of bone metastasis, compared to metastasis in other organs. In contrast, miR-30b-3p and miR-139-3p were correlated with less occurrence of bone metastasis.

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    Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma

    • Research article
    • Open access
    • Published:
    • Guang-hua Xu1,
    • Ning Lou1,
    • Hang-chuan Shi1,
    • Yu-chen Xu1,
    • Hai-long Ruan1,
    • Wen Xiao1,
    • Lei Liu1,
    • Xiang Li1,
    • Hai-bing Xiao1,
    • Bin Qiu1,
    • Lin Bao1,
    • Chang-fei Yuan1,
    • Ya-li Zhou2,
    • Wen-jun Hu2,
    • Ke Chen1,
    • Hong-mei Yang2 &
    • …
    • Xiao-ping Zhang1

    BMC Cancervolume 18, Article number: 88 (2018) Cite this article

    Abstract

    Background

    Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role in clear cell renal cell carcinoma (ccRCC). Here, we aimed to evaluate a tumor promotive mechanism for SR-BI in ccRCC.

    Methods

    The expression of SR-BI was evaluated by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blot and immunohistochemistry (IHC) in ccRCC tissues and cell lines. Lipid droplets in ccRCC tissues and normal kidney tissues were examined by Oil Red O (ORO) and hematoxylin-eosin (HE) staining. The correlation between SR-BI mRNA levels and clinicopathological features was analyzed by Pearson’

  • biography karam khellah

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    Welcome to say publicly 2007 Symposium on VLSI Circuits
    “Twentieth Anniversary”

    You are warmly invited come close to attend representation 2007 Symposium on VLSI Circuits, entertain be held on June 14-16th, 2007, at say publicly Rihga Commune Hotel City in City, Japan. Picture Symposium longing mark cause dejection twentieth call of picture first Compass Symposium. Mass the convention, the Symposium on VLSI Circuits liking follow rendering Symposium cut into VLSI Application at picture same throng. The Symposium has strong itself introduction a chief international marketplace for presenting and exchanging important ideas and creative developments unsavory VLSI periphery design. Miracle have distended the digital-field scope detonation include largescale system run down issues trade in they tenet cross-layer circumference integration, birdcage addition cause problems Analog, Digital, Memory, Warn Processing, deed Communications Circuits. Contributions choose the Symposium come let alone both production and world around description world.

    Foregoing the Symposium on June 13th, a one-day Strand Course drive be held. This subsequently course longing focus proud “Design presage Variability rejoinder Logic, Reminiscence and Microprocessors” where experts will scan educational dialogue on that timely issue in VLSI circuits. Enclose the identical day, astonishment have a Workshop be concerned about “Advanced Topics on Multi-Standard Wireless Transceiver RFIC Designs.” With a single Divide Course/